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Symbol
Name
ID 		Flt3
FMS-like tyrosine kinase 3
MGI:95559
Phenotype annotations related to immune system
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemias
Acute myeloid leukemia
Subacute progressive viral hepatitis
Disease(s) Associated with FLT3
acute lymphoblastic leukemia
acute myeloid leukemia
hepatocellular carcinoma

Mouse Phenotypes
enlarged spleen
abnormal B cell differentiation
increased pre-pro B cell number
decreased pro-B cell number
increased pro-B cell number
arrested B cell differentiation
abnormal myelopoiesis
myeloid hyperplasia
decreased neutrophil cell number
increased neutrophil cell number
increased granulocyte number
decreased plasmacytoid dendritic cell number
decreased dendritic cell number
increased dendritic cell number
decreased mature B cell number
decreased B cell number
decreased pre-B cell number
decreased NK cell number
decreased effector memory T-helper cell number
decreased T cell number
decreased lymphocyte cell number
increased monocyte cell number
decreased leukocyte cell number
increased leukocyte cell number
abnormal B cell morphology
abnormal spleen morphology
increased spleen red pulp amount
intermingled spleen red and white pulp
abnormal spleen white pulp morphology
increased spleen white pulp amount
decreased splenocyte number
abnormal NK cell physiology
abnormal macrophage physiology
decreased circulating interferon-alpha level
decreased circulating interferon-gamma level
decreased circulating interleukin-12 level
increased circulating interleukin-6 level
increased circulating tumor necrosis factor level
small lymph nodes
abnormal dendritic cell physiology
abnormal dendritic cell antigen presentation
decreased interferon-alpha secretion
decreased interferon-gamma secretion
decreased interleukin-12 secretion
increased susceptibility to Herpesvirales infection induced morbidity/mortality
increased susceptibility to Herpesvirales infection
increased susceptibility to Riboviria infection
Availability Mouse Genotype
Flt3em1(IMPC)Ccpcz/Flt3em1(IMPC)Ccpcz
Flt3m1Btlr/Flt3m1Btlr
Flt3tm1Dgg/Flt3tm1Dgg
Flt3tm1Irl/Flt3tm1Irl !
Flt3tm1.1Dosm/Flt3+
Flt3tm1Dgg/Flt3+
Flt3tm2.1Dosm/Flt3+
Flt3tm1Dosm/Flt3+
Tg(Mx1-cre)1Cgn/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory